Eular highlights? SSc trials near misses for efficacy. Abatacept v placebo in early diffuse scleroderma had begun primary outcome for skin but positive composite measure of response (CRISS) TCZ beg on skin but nearly significant; maybe less lung progression #EULAR2019 @RheumNow
— Janet Pope (@Janetbirdope) June 16, 2019
Eular highlights SLE Rx Belimumab in largest SLE RCT is safe. Ustikinumab decreases interferon in SLE- Eploratory results from + RCT. Maybe blood levels of hydroxychloroquine may reduce Retinopathy by decreasing dose if high and detect adherence if too low #EULAR2019 @RheumNow
— Janet Pope (@Janetbirdope) June 16, 2019
Eular highlights in scleroderma. Nintedanib + for SSc ILD. Positive correlations of combined response in SSc measure and PROs in RCT exploratory analysis of Lenabusum a cannabinoid receptor agonist, maybe riociguat helps Raynauds and digital ulcers #EULAR2019 @RheumNow
— Janet Pope (@Janetbirdope) June 16, 2019
Benefits of #physicalactivity in #rheumatoidarthritis
➡️Disease related outcomes
➡️Systemic outcomes
➡️Financial costsvia @NoreleeK #EULAR2019#Exercise #arthritis pic.twitter.com/5vnKaPdAQB
— Dr Ai Lyn Tan (@DrAiLynTan) June 13, 2019
Here's a 2 min snapshot of #physicalactivity uptake at #EULAR2019
➡️88% (23) used #escalator
➡️12% (3) used #stairs
➡️87% (20) on escalator stood still
➡️13% (3) walked on escalatorWell done all who used stairs!👍🏽
Good use of facilities & opportunitiespic.twitter.com/7NgdOBtc1z— Dr Ai Lyn Tan (@DrAiLynTan) June 17, 2019
RheumNow Podcast from EULAR19 is up! EULAR 2019 Streamin' (6.14.19). You can view it here>> https://t.co/fTdH4kuCJX or listen on iTunes or SoundCloud >> https://t.co/TGxUixKoIj
— Dr. John Cush (@RheumNow) June 17, 2019
RheumNow expanded twitter coverage of the #EULAR2019 annual meeting is sponsored by Horizon Pharma. All content chosen by RheumNow & its Faculty.
— Dr. John Cush (@RheumNow) June 16, 2019
#EULAR2019 commentary on RheumNow's meeting coverage site: https://t.co/5zpSSNXARC – hope you check it out. It features tweets, video interviews, articles and more. Our final meeting wrap up hits tomorrow. Hope everyone had safe travels home.
— Dr. John Cush (@RheumNow) June 16, 2019
Eular highlights. Unanswered questions. Need RCTs in severe RA with targeted DMARD + biological? Should we cycle JAKs – need RCT. ?change target in RA to reflect real disease activity- inflammation and consider PROs separately #EULAR2019 @RheumNow
— Janet Pope (@Janetbirdope) June 16, 2019
Eular highlights. Need to know if order of Rx of advanced therapies makes a long term difference in RA and PsA. ?better effectiveness or retention with one strategy vs another. ?too much drug cycling #EULAR2019 @RheumNow
— Janet Pope (@Janetbirdope) June 16, 2019
Bad news. Chikungunya has arrived to Spain. The mosquito bites happened last May in Alicante.
Tres turistas islandeses en Alicante, primeros infectados de chikungunya en España https://t.co/v89dEVyFHr vía @el_pais— Emilio Martin Mola (@emartinmola) June 14, 2019
Interesting talks from @GeorgeTsokos. Response to Ustekinumab in #lupus trial was associated with reduction in IFN-gamma (IFN-II) but not IL17 (A & F), 22 or IFN-I signature (IFN-alpha) #EULAR2019 pic.twitter.com/xZP4qjSUnH
— Md Yuzaiful Md Yusof (@Yuz6Yusof) June 14, 2019
Major Unanswered Question: according to EULAR Recommendations a regular follow-up and monitoring of disease activity in patients with large vessels vasculitis is recommended
👉🏻But how often❓
👉🏻Is imaging useful at all❓
👉🏻How to screen for vessel stenosis & aneurysms❓#EULAR2019 pic.twitter.com/xFvq1qfIGN— Juan Ovalles, MD, PhD (@DrJuanOvalles) June 12, 2019
Fibromyalgia Rx in EULAR guidelines includes amitryptylline which won the vote and duloxetine and neurontin or gabapentin which others chose. New thinking is to decide on Rx by type of pain. Don't forget exercise, sleep hygiene, CBT #EULAR2019 @RheumNow https://t.co/XEKG6WBU1i
— Janet Pope (@Janetbirdope) June 15, 2019
Pts with RA have shame and guilt which correlates with demographics and disease activity. Something to think about, acknowledge and give proper help. FRI0030 #EULAR2019 @RheumNow
— Janet Pope (@Janetbirdope) June 15, 2019
More in #gout news from #EULAR2019: men on uric acid-lowering therapy (and only 1/3 of people in this study were) were less likely to visit the #ER than those who weren’t
— CreakyJoints.org (@CreakyJoints) June 15, 2019
Low dose steroids in RA are benign? I speak to @dr_rachelblack about cataract and glaucoma risk from steroids for @RheumNow (data from SAT0592 at #EULAR2019) https://t.co/3Qo4dZdTNK pic.twitter.com/1kLQ2VwSD3
— David Liew (@drdavidliew) June 15, 2019
BIIB059 is a monoclonal antibody that blocks BDCA2, which inhibits the production of inflammatory mediators in SLE. A Phase 1 trial showed drug to be safe& tolerable. It continues being investigated in SLE& cutaneous #lupus. #EULAR2019 #InsideLupusResearch https://t.co/bbcV3W57DD
— Lupus Foundation of America (@LupusOrg) June 15, 2019
Clinical Highlights #EULAR2019: Emapalumab, an IFN- gamma blocking monoclonal antibody, is effective in macrophage activation syndrome in patients with childhood-onset #SLE #PReS2019 @carmona_loreto >LA
— ARD & RMD Open (@ARD_BMJ) June 15, 2019
We unfortunately missed out on it at #EULAR2019 but nice work and important paper from @CCalabreseDO @cappelliMD @MarieKostine @BetsyKirch @LCalabreseDO on PMR-like irAEs. An area worth exploring! https://t.co/IrEI7QzCPZ @RheumNow
— David Liew (@drdavidliew) June 15, 2019
You can stop MTX in RA pts in low disease state after adding tofa 11 mg daily long acting for 24 Wks if CDAI <11 (Oral Shift) No diff btw continue vs D/C MTX. Some pts will be happy to stop MTX without loss of effect LBOOO4 #EULAR2019 @RheumNow
— Janet Pope (@Janetbirdope) June 15, 2019
Sjogrens EULAR guidelines leave me dry! Lots of collaboration and work on guidelines but not much content which begs for RCTs in Sjogrens to help our pts. SP0190. But some recent RCTs recently + such as Leflunomide+ Hydroxychloroquine #EULAR2019 @RheumNow pic.twitter.com/JZDcBLHai8
— Janet Pope (@Janetbirdope) June 15, 2019
For PsA poly arthritis what do you usually start
— Janet Pope (@Janetbirdope) June 15, 2019